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In a series of fluorescence microscopy and biochemical studies, Epitalon was shown to enter the nuclei of human HeLa cells and bind selectively to DNA regions rich in CAG and ATTTC repeats, sequences that are common within promoter regions of the telomerase gene [1,32,33]

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Current Pharmaceutical Design, 20(7), 11211125

The compound's effects extend to muscle tissue, where NNMT inhibition modulates cellular energetics and contractile function

One of the primary obstacles is the gap between preclinical findings and clinical application, often referred to as the valley of death in drug development

This makes them valuable tools in sports medicine and rehabilitation